The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep
RN Upton, GL Ludbrook, EC Gray… - The Journal of the …, 1997 - pubs.asahq.org
Background Different opioids have different delays (hysteresis) between their concentrations
in blood and their cerebral effects. Possible mechanisms include differences in their rate of
penetration into the brain and differences in their distribution volume in the brain. There
have been few in vivo studies of the cerebral kinetics of opioids to differentiate these
mechanisms. Methods The cerebral kinetics of meperidine and alfentanil were examined
using conscious sheep that were fitted with long-term monitoring equipment to measure …
in blood and their cerebral effects. Possible mechanisms include differences in their rate of
penetration into the brain and differences in their distribution volume in the brain. There
have been few in vivo studies of the cerebral kinetics of opioids to differentiate these
mechanisms. Methods The cerebral kinetics of meperidine and alfentanil were examined
using conscious sheep that were fitted with long-term monitoring equipment to measure …
